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KMID : 0376219710080020319
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Chonnam Medical Journal
1971 Volume.8 No. 2 p.319 ~ p.329
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Relation between Carbon Tetrachloride-induced Liver Injury and Concentration of Carbon Tetrachloride in the liver
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Abstract
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In order to induce liver injury experimentally, under control in a pre determined degree, attempts were made to correlate the degree of Giver, injury induced by carbon tetrachloride with the concentration of carbon tetrachloride in rabbit liver,
1. The blood level of carbon tetrachloride decreased with finite after intraperitoneal administration, while the level in the liver increased by six hours after administration and then slowly decreased.
2. The triglyceride level in the blood increased slightly around one hour after carbon tetrachloride treatment and then decreased continuously below the pre-treatment level. Hepatic triglyceride level increased, rapidly, however, by 12 hours after the treatment and then decreased very slowly
3. Carbon tetrachloride inhibited the uptake -by liver of colloidal 198-Au given intravenously, leading to decreased clearance from blood of 198-Au and to a slightly enhanced uptake by the spleen.
4. Carbon tetrachloride, which is known to cause fatty liver, caused the appearance of fine lipid droplets around the central´, zone which later extended to the entire lobules with accompanying slight necrosis. Methyl green pyronin staining of the carbon tetrachloride treated liver indicated that changes in ribonucleic acid preceded changes in desoxyribonucleic acid. Alkaline phosphatase reaction which was not apparent early appeared slowly platter around the central veins and endothelial layers of sinusoids and extended gradually to the entire lobules.
5. It was possible to assess the degree of carbon tetrachloride induced liver injury from the concentration of carbon tetrachloride in the blood and liver together with the information of time after carbon tetrachloride treatment. From these results it was suggested that liver injury could be induced experimentally under control in a pre-determined degree by giving a pre-determined amount of carbon tetrachloride intraperitoneally and killing the animal at a pre-determined time interval.
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